This paper presents the results of 9-year biogeophysical monitoring (1998-2007) of spatial and time effects of space weather and atmospheric and climatic factors on the status of normal subjects, which was carried out simultaneously in geographical areas situated at different latitudes. Requirements to conditions of long-term telecommunication biogeophysical monitoring studies are formulated, providing the reliability and reproducibility of the experiment results. The results indicate that the role of atmospheric and climatic factors in modification of dynamic regimens of human body functioning is significantly higher in subjects living at lower latitudes. The spatial and time regularities of the effects of space and physical factors on human body were detected (the latitude, time, trigger, amplitude, synergetic, and cumulative effects of the population averaging of the reaction). These effects indicate that human body belongs to a class of open nonlinear dynamic systems with all characteristics intrinsic of it. © Springer Science+Business Media, Inc. 2008.