Hyperglycemia in patients with acute coronary syndrome (ACS) is one of main predictors of cardiovascular complications. Despite increasing number of proofs of prognostic value of elevated glycemia in patients with ACS and lowering of rate of clinical outcomes at the background of control of glycemia in patients with serious diseases there are no guidelines on diagnosis of the given state in patients hospitalized because of ACS and subsequent management of this category of patients. This can be explained by absence of reliable results of randomized clinical studies assessing interrelationship of parameters of glycemia, rates of early and remote cardiovascular and other complications as well as importance of achievement of adequate glycemic control and determination of target values of glycemia. Presented recommendations on management of patients with ACS in clinical practice require further confirmation and specification.