International Journal on Minority and Group Rights. Том 10. 2003. С. 203-220
A novel molecular platform for co-delivery of monomethyl auristatin E and ispinesib to prostate cancer cells
A conjugate for co-delivery of ispinesib and monomethyl auristatin E was prepared using methods of peptide synthesis and azide–alkyne cycloaddition. Cytotoxicity studies of the mentioned drug pair were performed. In vitro studies of the synthesized bimodal conjugate were conducted on prostate cancer cell lines. © 2025 Mendeleev Communications.
Авторы
Zyk Nikolay Y. 1 , Kolchanova Anastasia Yu 1 , Volkova Natalia S. 1 , Uspenskaya Anastasia A. 1 , Skvortsov Dmitry A. 1 , Beloglazkina Elena K. 1 , Zyk Nikolai V. 1 , Majouga Alexander G. 2 , Machulkin Alexey E. 1, 3
Журнал
Издательство
Royal Society of Chemistry
Номер выпуска
4
Язык
Английский
Страницы
440-443
Статус
Опубликовано
Ссылка
Том
35
Год
2025
Организации
- 1 Department of Chemistry, Lomonosov Moscow State University, Moscow, Moscow Oblast, Russian Federation
- 2 Mendeleev University of Chemical Technology of Russia, Moscow, Moscow Oblast, Russian Federation
- 3 RUDN University, Moscow, Moscow Oblast, Russian Federation
Ключевые слова
azide−alkyne cycloaddition; bimodal conjugates; ispinesib; monomethyl auristatin E; peptide synthesis; prostate cancer; prostate specific membrane antigen
Поделиться
Другие записи
Mendeleev Communications. Том 35. 2025. С. 440-443