Tryptophan Signaling Molecules in Children with Different Developmental Dynamics of Obesity

The high incidence of childhood obesity is a big healthcare challenge worldwide, which is fraught with the development of not only numerous somatic comorbidities but also children's social maladaptation. Searching for early biochemical markers of obesity stabilization and its progression at an older age is very important for identifying risk groups and preventing the development of obesity and its complications. Our study showed that the child' sex, which is often disregarded in these situations, should necessarily be considered when assessing the developmental dynamics of obesity. Whereas in girls, a decrease in serum serotonin concentrations may serve as a marker of obesity stabilization/progression, in boys, this tendency can be predicted by reduced serum indole-3-acrylate levels. In both sexes, elevated fecal indole-3-carboxaldehyde levels can be indicative of obesity stabilization/progression.