Clinical and Laboratory Profile of a Severe Patient with COVID-19

Purpose. To evaluate clinical and hematological parameters in COVID-19 inpatients associated with the severity of the disease. Materials and methods. A prospective study was conducted, including observation of 583 patients with COVID-19 treated in a hospital during the initial period of the pandemic in Moscow. The criteria for inclusion in the study were: persons age over 18 years, the presence of SARS-CoV-2 RNA in their biomaterial confirmed by RT-PCR. To analyze clinical and laboratory data, modern statistical methods were used, including the SPSS Statisticsvery program. 26 (IBM, USA), Python. Results. It was determined that for circumstantial confirmation of persistent viremia (SARS-CoV-2) and the activity of the infectious process, it is expedient to use dynamic monitoring of a set of acute-phase laboratory parameters, namely, the presence of a tenfold or more increase in CRP, an increase in ferritin more than 250 μg/l and an ESR of more than 30 mmHg. It was discovered that the severe course of the new coronavirus infection is significantly associated with the age criterion of patients (over 70 years old) and the presence of 4 or more concomitant diseases in patients (Mann – Whitney test =0.001, p≤0.05). Analysis of the hematological parameters of patients with severe COVID-19 demonstrated that significantly more often (χ2 criterion <0.001, p≤0.05) they had moderate leukocytosis (in 29.5% of cases), relative/absolute lymphopenia (65.4 % of cases) unexpressed thrombocytosis (58.1% of cases). Conclusion. A comprehensive assessment of the patient’s objective and premorbid status, differential and dynamic analysis of laboratory test results, along with the use of special diagnostic tests made it possible to opportunely determine the disease nosological form, severity, presence and nature of complications, as well as the severity and dynamics of the inflammatory process activity in patients with COVID-19. © 2025, Professionalnye Izdaniya. All rights reserved.