mRNA technologies in treatment of oncological diseases: global experience of clinical trials and implementation in the Russian Federation

Bagdasarova, Daria Valerievna; Bolotina, Larisa Vladimirovna; Leukhina, Irina A.; Shatalov, Peter A.; Revkova, Maria A.; Veselovskiy, E. M.; Karpulevich, Evgeny A.; Betelin, Vladimir Borisovich; Avetisyan, Arutyun I.; Pochtovyi, Andrei A.; Gushchin, Vladimir A.; Logunov, D. I.; Gintsburg, Alexander L.; Shegai, Petr Viktorovich; Kaprin, Andrey D.

мРНК-технологии в борьбе с онкологическими заболеваниями: мировой опыт клинических исследований и опыт внедрения в Российской Федерации

mRNA technologies in treatment of oncological diseases: global experience of clinical trials and implementation in the Russian Federation

Malignant neoplasms remain one of the leading causes of death worldwide, continuously driving the development and active implementation of new innovative treatments into clinical practice. This article provides a comprehensive review of the current status and prospects for the application of mRNA technologies in oncology, analyzing global clinical trial experience, the mechanism of action of therapeutic mRNA cancer vaccines, manufacturing processes, and the regulatory framework for the introduction of individual biotechnologically modified drugs (iBTMD) in the Russian Federation. © 2025, Media Sphera Publishing Group. All rights reserved.

Авторы

Bagdasarova Daria Valerievna ¹ , Bolotina Larisa Vladimirovna ¹ , Leukhina Irina A. ¹ , Shatalov Peter A. ² , Revkova Maria A. ¹ , Veselovskiy E.M. ¹ , Karpulevich Evgeny A. ³ , Betelin Vladimir Borisovich ^3, ⁴ , Avetisyan Arutyun I. ³ , Pochtovyi Andrei A. ^5, ⁶ , Gushchin Vladimir A. ^5, ^6, ⁷ , Logunov D.I. ⁵ , Gintsburg Alexander L. ^5, ⁶ , Shegai Petr Viktorovich ^2, ⁸ , Kaprin Andrey D. ^1, ^2, ⁸

Журнал

Онкология. Журнал им. П.А. Герцена

Издательство

Общество с ограниченной ответственностью Издательство Медиа Сфера

Номер выпуска

Язык

Русский

Страницы

69-77

Статус

Опубликовано

Ссылка

Внешняя ссылка

DOI

10.17116/ONKOLOG20251406169

Том

Год

2025

Организации

¹ P. A. Hertsen Moscow Oncology Research Center, Moscow, Russian Federation
² National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
³ Ivannikov Institute for System Programming of the RAS, Moscow, Russian Federation
⁴ National Research Centre "Kurchatov Institute", Moscow, Moscow Oblast, Russian Federation
⁵ N. F. Gamaleya Institute of Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russian Federation
⁶ Sechenov First Moscow State Medical University, Moscow, Russian Federation
⁷ Lomonosov Moscow State University, Moscow, Moscow Oblast, Russian Federation
⁸ RUDN University, Moscow, Moscow Oblast, Russian Federation

Ключевые слова

cancer vaccines; individual biotechnologically modified drugs (iBTMD); mRNA vaccines; personalized treatment; tumor neoantigenes

Цитировать

ГОСТ MLA RIS BibTex

Другие записи

AUTONOMY IN THE RUSSIAN FEDERATION: THEORY AND PRACTICE

Статья

Kartashkin V.A., Abashidze A.Kh.

International Journal on Minority and Group Rights. Том 10. 2003. С. 203-220

МРНК-ТЕХНОЛОГИИ В БОРЬБЕ С ОНКОЛОГИЧЕСКИМИ ЗАБОЛЕВАНИЯМИ: МИРОВОЙ ОПЫТ КЛИНИЧЕСКИХ ИССЛЕДОВАНИЙ И ОПЫТ ВНЕДРЕНИЯ В РОССИЙСКОЙ ФЕДЕРАЦИИ

Статья

Bagdasarova Daria Valerievna, Bolotina Larisa Vladimirovna, Leukhina Irina A., Shatalov Peter A., Revkova Maria A., Veselovskiy E.M., Karpulevich Evgeny A., Betelin Vladimir Borisovich, Avetisyan Arutyun I., Pochtovyi Andrei A., Gushchin Vladimir A., Logunov D.I., Gintsburg Alexander L., Shegai Petr Viktorovich, Kaprin Andrey D.

Онкология. Журнал им. П.А. Герцена. Том 14. 2025. С. 69-77