Бронхиальная астма у детей с первичной цилиарной дискинезией: два клинических наблюдения

Bronchial asthma in children with primary ciliary dyskinesia: two clinical cases

Primary ciliary dyskinesia (PCD) is a genetically determined disease characterized by structural and functional abnormalities of the cilia of the ciliated epithelium. Chronic cough, wheezing, and reversible bronchial obstruction in patients with PCD can mimic bronchial asthma (BA), leading to diagnostic and therapeutic errors. However, the combination of PCD and BA is possible and represents a special clinical situation. The article presents two clinical cases of children with genetically confirmed PCD (mutations in the CCDC39 and DNAH5 genes), in whom additional examination allowed for the diagnosis of BA. The prescription of inhaled glucocorticosteroids in combination with long-acting β2-agonists led to a sustained improvement in their condition, a reduction in the frequency of exacerbations, and an increase in exercise tolerance. The presented cases highlight the need for clinical awareness of the combination of PCD and BA, regular functional assessment of the respiratory system, and individualized therapy with mandatory regulation of physical activity and sports. © 2025, LLC MMA MediaMedika. All rights reserved.