Neuronal and extraneuronal noradrenaline uptake and condition of the adrenoreactive structures of an isolated rat heart with compensatory myocardial hypertrophy

It was demonstrated on an isolated heart preparation that the intensity of neuronal noradrenaline uptake by a hypertrophied heart diminishes as compared to that by a control 6 and 30 days after constriction of the abdominal aorta, and that extraneuronal uptake tends to intensify in 6 days and decreases significantly in 30 days. These changes, together with the reduced adrenoreactivity of a hypertrophied heart in vitro may in 30 days contribute to weakening of the adrenergic control of the heart in its compensatory hypertrophy and hyperfunction under conditions of chronic overloading by pressure.