Non-epithelial tumors (NO) of the gastrointestinal tract (GIT) are a large heterogeneous group of neoplasms. OIs are characterized by the absence of a pathognomonic clinical picture, as well as by the fact that they cause diffi culties both at the stage of endoscopic diagnosis and morphological examination. Often, the fi nal diagnosis can be established only after a complete morphological diagnosis of the removed tumor. In most cases, an immunohistochemical study is required to make the diagnosis. Understanding the endoscopic manifestations provides an essential aid in the diff erential diagnosis. The article presents a review of the literature on the choice of method for endoscopic and endoscopic diagnosis of rare non-epithelial tumors of the gastrointestinal tract. © 2023 Global Media Technologies. All rights reserved.