Annotation. The article is devoted to the study of quality and safety indicators of compound feeds made from agricultural and processing industry waste under the influence of microbiological fermentation. Compound feeds of the following formulation were studied: recipe No. 1: beer pellet -40%; wheat bran – 20.0 %; sunflower cake - 20%; mushroom substrate – 20%; recipe No. 2: beer pellet - 40%; wheat bran – 10.0%; sunflower cake - 10 %; mushroom substrate – 30%; recipe No. 3: beer pellet – 40%; wheat bran – 10.0%; sunflower cake - 20%; mushroom substrate – 20 %; recipe No. 4: beer pellet - 29%; wheat bran – 54.0%; sunflower cake - 17%; recipe No. 5: beer pellet – 25%; soy – 75.0%. The purpose of our research was to study the quality and safety indicators of compound feeds made up of agricultural and processing industry waste after microbiological fermentation with Lesnov's starter culture. It has been established that recipes No. 5 and No. 4 are the most preferable in terms of the content of metabolic energy for cattle, sheep, pigs and poultry. The content of mycotoxins (aflatoxin B1, deoxynivalenol, zearalenone, ochratoxin A, T-2 toxin), microscopic mold fungi and yeast, pesticides (malathion, pyrimithophosmethyl, cypermethrin, diflubenzuron), nitrates and nitrites, lead, arsenic, cadmium and mercury in fermented compound feeds of various formulations did not exceed MDU; GMO not detected. When choosing recipes, it is necessary to take into account the physico-chemical parameters of fermented compound feeds and the peculiarities of animal digestion (single-chamber or multi-chamber stomachs). © The Authors, published by EDP Sciences.