EARLY-ONSET GASRTRIC CANCER (REVIEW)

Objective. Early-onset gastric cancer (EOGC) constitutes a serious medical and social problem. Early-onset gastric cancer accounts for approximately 6% of all malignant epithelial neoplasms. Material and Methods. We reviewed retrospective and prospective randomized trials using Medline and Elibrary databases. Results. The applied significance of the molecular genetic classifications consist in the formation of groups for evaluating prognosis of the disease using multifactorial analysis. This classification indicates that EOGC diagnosed at a locally advanced stage and primary dissemination is most often caused by GS (TCGA) and MSS/EMT(ACRG) subtypes and is characterized by mutations in CDH1, RhoA, CLDN18-ARHGAP genes. These changes are accompanied by the prevalence of diffuse histological type of gastric cancer according to the Lauren classification and ulcerated or infiltrative type according to the Borrmann classification (type III and IV) with the presence of high-grade adenocarcinoma with a signet ring cell component. Conclusion. Considering the aggressiveness of gastric cancer in young patients, who more frequently present with locally advanced and metastatic disease at the time of diagnosis, there is a need for increased cancer alertness among physicians of other specialties, early endoscopic controls to detect cancer at early stages and benefit from both surgical and multimodal treatment. © 2023, Tomsk National Research Medical Center of the Russian Academy of Sciences. All rights reserved.

Авторы
Pugaev D.M. , Lyubchenko L.N. , Ryabov A.B. , Kaprin A.D.
Издательство
Tomsk National Research Medical Center of the Russian Academy of Sciences
Номер выпуска
6
Язык
Русский
Страницы
153-171
Статус
Опубликовано
Том
22
Год
2023
Организации
  • 1 Kommunarka Moscow Multidisciplinary Clinical Center, Moscow City Health Department, 8, Sosensky Stan St, pos. Kommunarka, Moscow, 108814, Russian Federation
  • 2 National Medical Research Radiological Centre of the Ministry of Health of the Russia, 4, Koroleva St, Obninsk, 249036, Russian Federation
  • 3 N.A. Lopatkin Research Institute of Urology and Interventional Radiology – branch National Medical Research Radiological, Centre of the Ministry of Health of the Russia, 51, build. 1, 3rd Parkovaya St, Moscow, 105425, Russian Federation
  • 4 P.A. Hertsen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russia, 3, 2nd Botkinsky Drive, Moscow, 125284, Russian Federation
  • 5 RUDN University, 6, Miklukho-Maklaya St, Moscow, 117198, Russian Federation
Ключевые слова
CDH1; CLDN18-ARHGAP; early-onset gastric cancer; molecular classification; RhoА
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