Influence of vitamin D on the reconstitutional processes of bone tissue: a review; [Влияние витамина D на реконструктивные процессы костной ткани (обзор)]

The article presents a generalized structured review of the results of various research works aimed at the analysis of the effect of vitamin D in the prophylaxis of oral cavity diseases, on the osseointegration of dental implants, on the bone marrow formation, on the periodontal tissue condition, and on the general state of the immune system in patients after surgical interventions. At present, the processes of bone tissue regeneration period reduction is the real problem not only in the field of maxillofacial surgery, but also in surgery in general. Objective — to analyze domestic and foreign literature sources for information on the effect of vitamin D on the regenerative processes of the maxillofacial region. The aim of the research is to study the influence of vitamin D on reconstructive processes of bone tissues and oral cavity condition in patients after surgical interventions when this metabolite is added to the complex therapy. The article contains general medical information about vitamin D: the ways of its entrance and metabolism in the organism, as well as its interaction with other substances and their influence on homeostasis processes; the recommended rates of this metabolite in a human body are presented, its influence on regeneration of bone tissue and healing of postoperative wounds, the results of clinical and laboratory researches in different fields of dentistry, covering the influence of vitamin D on the state of oral cavity in general. Conclusion. Due to the lack of widespread use of this drug in practice, it is recommended to reconsider the inclusion of the metabolite in the treatment of patients with diseases of the maxillofacial region on the basis of the presented data. Despite the existing recommended norms established by the WHO and the Endocrinology Association, it is necessary to develop a scheme of vitamin D administration in patients after surgical interventions in order to optimize and shorten the rehabilitation period, based on the evaluation of clinical data of patients. © 2023 The Author(s).