Cobalt-Catalyzed Carbonylation for the Synthesis of N-Heterocyclic Compounds

Nitrogen-based heterocyclic compounds are regarded as one of the most important classes of organic compounds among the applied branches of organic chemistry, with a substantial amount of research being dedicated to the advancement of novel molecules and composites. This chapter aims to sketch the synthesis of some of the important N-heterocycles from 2010 to 2020 mediated by Co catalyzed carbonylation reaction using CO directly or CO surrogates as CO source. Carbon monoxide, an abundant and inexpensive carbonyl source has been widely applied to synthesize carbonyl compounds which are spread along natural products, pharmaceuticals, and functional materials. The chapter summarizes the recent developments in carbonylation reactions by utilization of diisopropyl azodicarboxylates, benzene-1, 3, 5-triyl triformate and CO 2 as CO surrogates for carbonylation reactions toward N-heterocyclic compounds. An array of N-heterocyclic compounds having phthalimide, pyridoisoquinolinones, aliphatic amides, phthalimide derivatives with various substituents were successfully synthesized by using a cobalt as a catalyst and CO gas. © 2022 John Wiley and Sons Ltd. All rights reserved.