Dental implantation and radioprotectors after surgical treatment of head and neck oncology

Worldwide, head and neck cancer (HNC-Head Neck Cancer) is one of the most common types of neoplasms with an ever-increasing prevalence and mortality rate. The aim of the work is to improve the methods of restoring masticatory function in patients who previously received radiation and chemotherapy, dental implantation techniques with immediate loading and the use of radio detectors based on sodium deoxyribo-nucleate ("Coletex-Gel-DNA-L"). Materials and methods. The main group included 61 patients. For local radiation treatment, the drugs "Coletex-gel-DNA" and "Coletex-gel-DNA-L" were used. The control group included 77 patients who, for the prevention and treatment of radiation reactions of the mucous membranes of the oral cavity, used the classical method - applications of stone oils (olive, sunflower). Results. Of the 79 dental implants installed in patients of the second group, 17 implants were removed due to perimplantitis. The implant survival rate is 78.5% in the control group. Based on a follow-up period of 12 + 2 months, the survival rate of implants was calculated in patients of the main and control groups. when using the drugs "Coletex-gel-DNA" and "Coletex-gel-DNA-L", there was a decrease in the frequency of radiation reactions of the III degree from 66.8 to 24.6% compared with the classical method of prevention, I and II degrees of radi-oepithelitis prevail, the results are reliable (p <0.01). IV degree was not observed in any patient of both groups. Conclusion. The results obtained indicate the effectiveness of the use of the drugs "Coletex-gel-DNA" and "Coletex-gel-DNA-L" for the prevention and treatment of radiation reactions of the oral mucosa and pharynx in patients with malignant neoplasms of the oropharyngeal zone. In this regard, this drug may be recommended for use as a therapy to accompany radiation, chemoradiotherapy and combined treatment. The introduction into the practice of dentists, the algorithm of complex restoration of masticatory function in patients with a history of oncology is justified. It is possible to reduce side effects, improve the recovery process.