RISK OF ADVERSE PREGNANCY OUTCOMES IN WOMEN WITH POLYCYSTIC OVARY SYNDROME

Objective: To study the risk of adverse pregnancy outcomes in women with polycystic ovary syndrome Design: Population based cohort study. Participants: patient attending OPD in ChalmedaAnand Rao institute of medical sciences 100 births among women with a diagnosis of polycystic ovary syndrome and 100 births among women without such a diagnosis. Main outcome measures: Risk of adverse pregnancy outcomes (gestational diabetes, pre-eclampsia, preterm birth, stillbirth, neonatal death, low Apgar score (<7 at five minutes), meconium aspiration, large for gestational age, macrosomia, small for gestational age), adjusted for maternal characteristics (body mass index, age), socioeconomic factors Results: Women with polycystic ovary syndrome were more often obese. Polycystic ovary syndrome was strongly associated with pre-eclampsia and very preterm birth and the risk of gestational diabetes was more than doubled. Infants born to mothers with polycystic ovary syndrome were more prone to be large for gestational age and were at increased risk of meconium aspiration and having a low Apgar score (<7) at five minutes Conclusions: Women with polycystic ovary syndrome are at increased risk of adverse pregnancy and birth outcomes These women may need increased surveillance during pregnancy and parturition.