The development of enterprises and organizations in the new conditions created by the COVID-19 pandemic raises many problems and sets new challenges. This article examines issues related to the changing operating conditions of regional companies, their use of digital technologies and the development of e-commerce. The relevance of the work is dictated by extensive discussion of these issues in the media and field research to determine the readiness of companies to transition to digital technologies. The need for this transition is apparent. Both positive and negative aspects of the transition to new working conditions have been identified based on the results of a content analysis of open sources of information. Digital technologies enable more flexible and dynamic development of companies, comprehensive services to their customers through the creation of service ecosystems. Electronic commerce is developing rapidly. At the same time, digitalization can divide the team, increase control (and therefore pressure) on personnel, and cause emotional burnout of employees. Consideration of these areas and a set of digitalization tasks is the main topic of this publication.