Разработка мягкой лекарственной формы на основе наночастиц металлов

Разработан состав и создан лабораторный регламент получения мазей с наночастицами меди на основе производных метилцеллюлозы: метилцеллюлозы водорастворимой (МЦ-100), гидроксипропилметилцеллюлозы (ГПМЦ), натрий-карбоксиметилцеллюлозы. Проведена оценка качества и стабильность мазей с наночастицами меди. Установлено, что наилучшими консистентными свойствами обладают мази с наночастицами меди на основах МЦ-100 и ГПМЦ. Предложена сканирующая электронная микроскопия в качестве метода для определения подлинности мягких лекарственных форм с наночастицами металлов.

Development of pharmaceutical dosage forms based on metal nanoparticles

The research presented in the article, focuses on the development of technology for pharmaceutical dosage forms with metal nanoparticles. As an active substance copper nanoparticles with desired physical and chemical characteristics and demonstrating high biological activity were used. We focused our efforts at the development of composition and laboratory regulations for production of ointments with copper nanoparticles (NPs) based on derivatives of methylcellulose: a water-soluble methyl cellulose (MC-100), hydroxypropyl methylcellulose (HPMC), sodium carboxymethyl cellulose (Na-CMC). Quality control of ointments with copper nanoparticles was performed for parameters: «Appearance», «uniform», «Colloidal stability», «Water content and volatile», «pH» and «viscosity». Samples of obtained ointments were white, homogeneous in composition, without mechanical impurities, with a weak characteristic odor. The pH of ointments was in the range of 5.0 to 6.8, which is close to the physiological pH of the skin. Mean mass fraction of water and volatile matter was 75.5 %. Ointments were resistant to separation by centrifugation upto 7000 rev/min. Ointments with copper nanoparticles on the basis of MC-100 and HPMC were found to have the best consistency. An evaluation of the quality and stability proves that ointments, prepared by this process flow, meet the requirements of ND limits for pharmaceutical dosage forms. To determine the authenticity of pharmaceutical dosage forms with metal nanoparticles a scanning electron microscopy was used.