СОСТОЯНИЕ ТРОМБОЦИТАРНОГО И КОАГУЛЯЦИОННОГО ГЕМОСТАЗА У БЕРЕМЕННЫХ ЖИТЕЛЬНИЦ ОБЬ-ИРТЫШСКОГО БАССЕЙНА С ХРОНИЧЕСКИМ ОПИСТОРХОЗОМ

Opisthorchiasis that is widely spreading in Russia and CIS countries was and remains a serious social, medical, and scientific problem. Local or imported cases ofopisthorchiasis have been notified in 87.6% of the administrative territories of Russia. The world’s largest focus ofopisthorchiasis is the Ob-Irtysh river basin with naturalpreconditions for its high infection in fish. The main clinical manifestations of Opisthorchis infestation are associated with liver damage caused by the obligate presence of Opisthorchis in the bile capillaries with evolving cholangitis,cholangiocholecystitis, and cholangiopancreatitis. Opisthorchis complicates the course of many diseases, affectinggestation, labor, and postpartum. The state of thrombocyticand coagulation hemostasis was analyzed in different period of pregnancy and postpartum (days 2-4), by using thecourse of pregnancy in the inhabitants of the hyperendemic focus of Opisthorchis infestation (the Ob-Irtysh basin)as an example. In the newcomers, pregnancy develops inthe presence of platelet hvperaggregation and acceleratedcontinuous blood clotting. In pregnant women who belongto native little peoples (Khanty, Mansi), opisthorchiasisinduces no significant changes in the hemostatic potential.