Антитела против Trypanosoma cruzi у интактных мышей и их онкопротекторный эффект

Antibodies against Trypanosoma cruzi in intact mice and their oncoprotective effect

Trypanosoma cruzi antibodies that are important in the anticancer effect of this species of Trypanosoma were first detected in 14% of the 374 examined intact mice. These background antibodies were polyclonal, i.e. they reacted with one or other of 9 genetically different T.cruzi clones and detected antigenic determinants in different structures of a Trypanosoma cell. Their spread in the population varied with animal batches; the liters were not greater than 1:40 and the level remained steady during a one-month observation. The growth of Ehrlich's adenomacarcinorna inoculated to these mice was inhibited by 1.5-2.5 times and, in some cases, terminated in total regression. The paper discusses the capacities of such antibodies in man and their inductor-commonness of the antigens of the normal intestinal microflora and the cells of the vertebrate with T.cruzi.