Формирование и реализация алкогольной зависимости у крыс после каротидной гломэктомии.

Проанализированы процессы становления и реализации влечения к алкоголю крыс, подвергнутых каротидной гломэктомии.

Formation and Realization of the Alcohol Dependence in Rats Following Carotid Glomectomy.

We have demonstrated that the carotid golmectomy significantly reduces the desire to consume alcohol in rats whose alcohol dependency has been formed over a 12-week period. Compared to the pre-surgery level, over the four-week period, post-glomectomy alcoholized rats are consuming lesser (as a weekly average) quantities of ethanol delivered together with water. The volume of the consumed water increases reliably by the third and the 4^th weeks after the surgery. The control shame-operation has no influence on the consumption of ethanol and water in the alcoholized rats. We are discussing the possible participation of the local renin-angiotensin system of the carotid body's receptor cells in the systemic mechanisms of the alcohol dependency.