Изменения головного мозга при болезни Иценко-Кушинга, выявляемые методом магнитно-резонансной томографии

Brain Changes in Patients with Cushing Disease, Revealed by Magnetic Resonance Imaging

The article deals with magnetic resonance semiotics of brain changes at Cushing disease one of the most serious neuroendocrine disorders with a typical clinical symptomcomplex caused by a chronic excess of glucocorticoids. We examined 53 patients with first revealed Cushing disease. In dependence on a type of changes in a brain the patients divided into three groups: ones with an isolated hydrocephaly, mainly outside, less often combined outside and intrinsic; patients with an isolated damage of a white matter mainly as diffuse perivascular encephalolysis; and patients with a combined damage of a brain: outside (sometimes plus intrinsic) a hydrocephaly and a diffuse lesion of a white matter. It is the most frequent type of brain's lesion, which degree depends on duration and a gravity of the disease. In addition to the changes specified earlier in literature, becoming apparent as brain atrophy, which results in a development of an outside and intrinsic hydrocephaly, the authors discussed a perivascular atrophy of a white matter in addition of a typical magnetic resonance patterns Cushing disease.