Рецепторы к стероидным гормонам при гиперпластических процессах в эндометрии

Steroid gormons receptors and endometrial hyperplasia

The endometrial hyperplastic processes is characterized by major variety of clinical currents. Main feature of "spontaneous endometrial hyperplasia" is complete normalization after total curettage; there is also proof hyperplasia with recurring. The purpose of present research was to carry out clinical and morphological correlations between various types of endometrial hyperplasia and expression estrogens (ERs) and progesterone (PR) receptors. We performed analysis of 150 patients with histologicaly documented simple endometrial hyperplasia without atypia: 75 women (50 %) had spontaneous recover after total curettage, at 50 (33 %) patients endometrium get well after gestagen treatment and in 25 (17 %) cases persistent recurring of hyperplasic processes was observed during 2-5 years. Immunohistochemical research have shown, that ERs and PR was intensive expressed in nuclei of all glandular epithelium and cells of storm at sections with spontaneous or treated simple hyperplasia with recovering. The intensity of reaction corresponded to middle and late stages of proliferation phase in normal endometrium. ERs and PR expression had mosaic picture in samples of recurring hyperplasia: about 2/3 of glands highly expressed ERs and PR in the nuclei of glands, while others, had weak reaction. Thus expression of the ERs and PR in nuclei of glandular cells in endometrium at simple hyperplasia, allows predicting the subsequent recurring.