Гемомикроциркуляция в базально-клеточной карциноме при фотодинамической терапии

Blood microcirculation in basal cell carcinoma under photodynamic therapy

In patients with basal cell carcinoma (BCC) skin microcirculation was measured by the laser Doppler flowmeter (LDF). Spectral analysis of LDF-signal based on fast Fourier transformation enables us to evaluate an amplitude and predominated frequency of flux motions in the following ranges: oc-rhythm (1-3 cycles/min, or min-¹), (3-rhythm (4-8 min-¹), y-rhythm (9-11 min-¹), high-frequency rhythm (HF - 12-30 min¹) and cardiorhythm (CF - 50-90 min-¹). For photodynamic therapy (PDT) hematoporphyrin derivative was administered intravenously in dosage 1-2 mg/kg. In 24 hours after that all patients were exposed to the red laser irradiation (0.69 pm) in dose 200-300 J/cm². The mircocirculation level in BCC was higher that in the areas of healthy skin (13.1 ±1.18 a.u. against 8.1 ±0.96 a.u. respectively, p<0.01). Exactly after PDT the marked decrease of microcirculation up to 4.7±0.63 a.u. associated with photoinduced stasis took place in the tumor. Spectral analysis of flux motions demonstrated a significant inhibition of a-, p-rhythms and amplification of HF- and CF-rhythms. In 1 week after PDT we observed a gradual restoration of microcirculation in the zone of PDT skin injury that followed a wound healing process.