The article characterizes geochemistry and petrogenesis of granitoids of the Syrostan Massif located southwest of the town of Miass, in the zone of the main deep fault in the Urals. The geochemistry of the collected samples from Syrostan was analyzed using ICP-MS and the X-ray fluorescence. Granite is rich in silicon oxide SiO2 at its concentrations from 59.54 to 76.14 wt.%. The rocks are from metaluminous to peraluminous and belong to the high-K calc-alkaline to weakly calc-alkaline series; granite is type I and has A/CNK < 1. The test samples feature the higher content of LREE as compared with HREE, the ratios (La / Sm)N from 3.5 to 6.5 and (Gd /Yb)N from 1.25 to 2.8, and the negative Eu anomaly. The revealed negative Nb anomalies and the ratio Nb/Ta (8-16) <17 point at depletion of mantle melts. These results can be reflective of the granite formation in the tectonic environment of the volcanic arc. Understanding of the petrogenesis of granitoids in the Syrostan Massif can help predict commercial accumulations of rare metals in it.