ESP teaching in the blended learning environment has become quite widespread in language classes worldwide. The purpose of this present study is to outline an effectiveness of ESP blended learning based on the use of the smart coursebook. A total of 48 EFL undergraduate students of a non-linguistic university participated in the study. The experimental group studied the target course through blended learning strategies, and their performance was evaluated through comparing the results got from a pretest and post-test, respectively, to check the effectiveness of ESP blended learning based on the use of the smart coursebook. Questionnaires were also conducted to identify students’ evaluation of the ESP blended learning. It was observed that the participants of the study perceived BL to be useful and helpful for the improvement of their English proficiency. The findings show that the participants in the experimental group received higher scores for their post-test at the end of the study. © 2018, Slovenska Vzdelavacia Obstaravacia. All rights reserved.