An hour in the morning is worth two in the evening: association of morning component of morningness–eveningness with single nucleotide polymorphisms in circadian clock genes

Sub-constructs of morning–evening preference might be differentially related to polymorphisms in circadian clock genes. We previously reported significant association between a single nucleotide polymorphism in PER3 (rs2640909) and Morning but not Evening Lateness scale of the Sleep–Wake Pattern Assessment Questionnaire. To further explore such a scale-specific relationship, seven single nucleotide polymorphisms in five circadian clock genes were studied using exploratory and confirmatory samples (in total, n = 698). The association of rs2640909 with Morning Lateness scale was not replicated in the confirmatory sample but remained significant in the merged sample. Moreover, we found and confirmed an association of this scale with rs1159814 in RORα. The results provided further evidence for differential relationship of polymorphisms in circadian clock genes with morning and evening components of morning–evening preference. We also suggested possibility to take into account the pattern of geographic variation in allele frequency for prioritization of circadian clock polymorphisms in candidate gene studies. © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Авторы
Dorokhov V.B.1 , Puchkova A.N.1, 2 , Taranov A.O.1 , Slominsky P.A.3 , Tupitsina T.V.3 , Ivanov I.D.4 , Vavilin V.A.4 , Nechunaev V.V.5, 6 , Kolomeichuk S.N.7 , Morozov A.V.7 , Budkevich E.V.8 , Budkevich R.O.8 , Dementienko V.V.9 , Sveshnikov D.S. 10 , Donskaya O.G.11 , Putilov A.A.11
Издательство
Taylor and Francis Ltd.
Номер выпуска
4
Язык
Английский
Страницы
622-642
Статус
Опубликовано
Том
49
Год
2018
Организации
  • 1 Laboratory of Sleep/Wake Neurobiology, The Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences, Moscow, Russian Federation
  • 2 Center for Cognition and Communication, Pushkin State Russian Language Institute, Moscow, Russian Federation
  • 3 Laboratory of Molecular Genetics of Hereditary Diseases, The Institute of Molecular Genetics of the Russian Academy of Sciences, Moscow, Russian Federation
  • 4 Laboratory of Drug Metabolism and Pharmacokinetics, The Research Institute for Molecular Biology and Biophysics, Novosibirsk, Russian Federation
  • 5 Chair of Personality Psychology, Novosibirsk State University, Novosibirsk, Russian Federation
  • 6 Chair of Social Work, Novosibirsk State Pedagogical University, Novosibirsk, Russian Federation
  • 7 Laboratory of Genetics, Institute of Biology, Karelian Research Centre, Russian Academy of Sciences, Petrozavodsk, Russian Federation
  • 8 Laboratory of Nanobiotechnology and Biophysics, North-Caucasus Federal University, Stavropol, Russian Federation
  • 9 Laboratory of Medical Electronics, Kotelnikov Institute of Radio Engineering and Electronics, Russian Academy of Science, Moscow, Russian Federation
  • 10 Department of Normal Physiology, Medical Institute, Peoples’ Friendship, University of Russia, Moscow, Russian Federation
  • 11 Research Group for Math-Modeling of Biomedical Systems, The Research Institute for Molecular Biology and Biophysics, Novosibirsk, Russian Federation
Ключевые слова
candidate gene; chronotype; CLOCK; NPAS2; PER2; PER3; RORA; SNPs
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/6540/
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