Three-Component Synthesis of Tetrahydroisoquinolines via SNVin Reaction

Abstract: The three-component reaction of carbocyclic enamino ketones, CH acids, and electrophiles has been studied. Previously unknown 5,6,7,8-tetrahydroisoquinoline derivatives have been synthesized via nucleophilic vinylic substitution (SNVin). The structures of some of the obtained compounds have been determined by X-ray analysis. © Pleiades Publishing, Ltd. 2024.

Авторы
Dyachenko I.V. , Dyachenko V.D. , Dorovatovskii P.V. , Khrustalev V.N. , Nenajdenko V.G.
Журнал
Russian Journal of Organic Chemistry
Номер выпуска
9
Язык
Английский
Страницы
1619-1629
Статус
Опубликовано
Ссылка
Внешняя ссылка
DOI
10.1134/S107042802409001X
Том
60
Год
2024
Организации
  • 1 Lugansk State Pedagogical University, Lugansk, 291011, Russian Federation
  • 2 “Kurchatov Institute” National Research Center, Moscow, 123182, Russian Federation
  • 3 Peoplesʼ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 4 Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
  • 5 Faculty of Chemistry, Moscow State University, Moscow, 119991, Russian Federation
Ключевые слова
5,6,7,8-tetrahydroisoquinolines; alkylation; CH acids; enamino ketones; nucleophilic vinylic substitution; three-component reactions
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