Состояние кожных покровов у мышей при воздействии антропогенных факторов

Skin condition of mice under impact of anthropogenic factors

The toxic impact of anthropogenic factors in macroorganism can initiate autoimmune processes, involving dermis, which can cause early manifestations of genodermatoses. This factor in the agricultural region of Russia needs to be studied. Genetic mutations, congenital malfor-mations of intrauterine growth and high dermatosis morbidity can be caused by environmental mutagens. Objective. To study the impact of anthropogenic factors on the skin of mice and their genotoxity in the first offspring. Material and methods. The experimental SHK outbred mice (n=84) were divided into 6 cages. Each cage included 10 females and 4 males. The exposure of pesticides and electromagnetic telephone’s radiation were studied. Results. In the examination of animals, dynamics of such indicators as average body weight, hair care, activity, intoxication symptoms and clinical pattern were observed, and the skin detmatoscopy of experimental series of mice and their first offspring was conducted. In the «Demi-tan» series the microcirculatory dysfunction in the auricle’s skin and in all experimental mice (except control), namely disruption of foot skin integrity in the form of erosion, rhagades and scales were established. Hyperemia and secondary efflorescences were present in the back skin of newborns from test series on the 2nd day of life, and erosion, crusts and voluminous desquamation appear by the 5th-6th week of life. Conclusion. The obtained results suggest embryotoxic impact of pesticides on the foetus of mice, manifested in the postnatal period by skin pathology, developmental delay and death in the first month of life. Disruptions of corneal layer integrity have been observed in adults with endogenous impact of anthropogenic factors in the first 1—2 months. © 2023, Media Sphera Publishing Group. All rights reserved.