Modern advances in molecular and cellular biology in the treatment of glioblastoma

Gliomas are the most common group of primary brain tumors, accounting for at least 80% of all types of central nervous system neoplasias. High-grade gliomas (anaplastic astrocytoma and oligodendroglioma, anaplastic pleomorphic xanthoastrocytoma, as well as three molecular genetic subtypes of glioblastomas) deserve special attention due to a poor prognosis for patient survival. A search for literature sources in the Russian and foreign databases has demonstrated that there are few studies of new treatments for highgrade gliomas, including glioblastomas. Combining the results of these studies has been an impetus to write this literature review. © I.A. STEPANOV