Benign-by-design sustainable protocol for the synthesis of furosemide

This study discloses a benign-by-design synthetic protocol for furosemide using a biomass-derived active pharmaceutical ingredient. The optimized protocol, designed for efficiency, was implemented within an hour using a microwave reactor and a range of environmentally friendly solvents. Investigations were carried out to assess the influence of additives and reaction media on the synthesis process. Green metrics were measured to propose an environmentally sound protocol aiming to minimize waste generation. These findings advance the development of a sustainable and efficient synthesis route for furosemide. © 2024