A POSSIBILITY FOR HEALTH IMPROVEMENT IN OVERWEIGHT AND OBESE WOMEN AT THE STAGE OF PREGRAVID PREPARATION

About half of women planning pregnancy have too much adipose tissue, insulin resistance, hypothalamic-pituitary-ovarian axis disorders, and consequently anovulation and infertility. Objective: To assess the results of using the biologically active dietary supplement Dikirogen (myo-inositol and D-chiroinositol in a ratio of 5:1) in conjunction with combination therapy for anovulation in overweight and obese women. Materials and methods: During 2021–2022, a descriptive study assessing the results of lifestyle changes (in diet and exercises) and nutritional support (a combination of myo-inositol 1000 mg and D-chiroinositol 200 mg, folic acid 200 μg, and manganese 5 mg (Dikirogen) was conducted in the clinics of Moscow, Nizhny Novgorod, Novosibirsk, Krasnodar, Yekaterinburg, and Voronezh in 197 reproductive-aged women who had overweight or obesity and anovulation for 2–4 months. Results: The use of the biologically active dietary supplement Dikirogen in conjunction with combination therapy (diet + exercises) caused decreases in body weight by 2.5 kg, body mass index (BMI) by 0.5 kg/m2, and waist circumference by 1.75 cm. The normal menstrual cycle was 1.41 times more often observed at Visit 2. There were reductions in LH levels from 8.45 (3.91) to 6.4 (4.9; 8.8) mU/ml and in the LH/FSH ratio from 1.4 (0.9; 2.0) to 1.2 (0.8; 1.6) (p<0.0001). There were also significant decreases in fasting glucose levels from 5.0 (4.5; 5.5) to 4.8 (4.2; 5.0) mmol/l (p<0.0001) and on the number of women with fasting glucose levels above 5.1 mmol/ml by 3.07 times. During 80–90 follow-up days, pregnancy occurred in 30 (15.2%) patients; at Visit 2, the ovulation test was positive in 96 (48.73%) women. Conclusion: The results of the study can recommend Dikirogen containing myo-inositol and D-chiroinositol in a ratio of 5:1, folic acid, and manganese in conjunction with combination therapy (diet, exercises) to obese and overweight women with complaints of anovulation and failure to achieve pregnancy,. © A group of authors, 2023.