Objective. To evaluate the immediate results of primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction (STEMI) with preserved antegrade blood flow, depending on the performance of balloon predilatation before coronary stent implantation or direct stenting. Material and methods. The study included 326 patients with STEMI and preserved antegrade blood flow (TIMI 1–3) during coronary angiography. The patients were divided into 2 groups: the first included 108 patients who underwent balloon predilatation before implantation of a coronary stent, and the second included 218 patients who underwent direct stenting of the infarct-associated coronary artery. Results. The study found that direct stenting in patients with STEMI was characterized by a statistically significantly lower risk of slow- and no-reflow phenomenon (p=0.001, Pearson’s Chi-square) and, as a result, better functional outcomes of treatment of patients (the degree of chronic heart failure according to N.D. Strazhesko, V.Kh. Vasilenko and left ventricular ejection fraction), which were also statistically significant (p=0.001, Pearson’s Chi-square). Conclusion. Direct stenting was a more favorable effect on the treatment outcomes of patients with STEMI, restoration of the contractile function of the left ventricle, and immediate clinical outcomes and can be considered in patients with STEMI and preserved antegrade blood flow (TIMI 1–3) as the method of choice for PCI in patients with STEMI. © 2023 Bakoulev National Medical Research Center for Cardiovascular Surgery. All rights reserved.