Neutrophil to lymphocyte ratio and in-hospital mortality among patients with SARS-CoV-2: A retrospective study

The goal of this study was to investigate in-hospital mortality in patients suffering from acute respiratory syndrome coronavirus 2 (SARS-CoV-2) relative to the neutrophil to lymphocyte ratio (NLR) and to determine if there are gender disparities in outcome. Between February 26 and September 8, 2020, patients having SARS-CoV-2 infection were enrolled in this retrospective cohort research, which was categorized by NLR levels ≥9 and < 9. In total, 6893 patients were involved included of whom6591 had NLR <9, and 302 had NLR ≥9. The age of most of the patients in the NLR<9 group was 50 years, on the other hand, the age of most of the NLR ≥9 group patients was between 50 and 70 years. The majority of patients in both groups were male 2211 (66.1%). The ICU admission time and mortality rate for the patients with NLR ≥9 was significantly higher compared to patients with NLR <9. Logistic regression's outcome indicated that NLR ≥9 (odds ratio (OR), 24.9; 95% confidence interval (CI): 15.5–40.0; p < 0.001), male sex (OR, 3.5; 95% CI: 2.0–5.9; p < 0.001) and haemoglobin (HB) (OR, 0.95; 95% CI; 0.94–0.96; p < 0.001) predicted in-hospital mortality significantly. Additionally, Cox proportional hazards analysis (B = 4.04, SE = 0.18, HR = 56.89, p < 0.001) and Kaplan–Meier survival probability plots also indicated that NLR>9 had a significant effect on mortality. NLR ≥9 is an independent predictor of mortality(in-hospital) among SARS-CoV-2 patients. © 2022 The Authors

Авторы
Al-Mazedi M.S. , Rajan R. , Al-Jarallah M. , Dashti R. , Al Saber A. , Pan J. , Zhanna K.D. , Abdelnaby H. , Aboelhassan W. , Almutairi F. , Alotaibi N. , Al Saleh M. , AlNasrallah N. , Al-Bader B. , Malhas H. , Ramadhan M. , Brady P.A. , Al-Zakwani I. , Setiya P. , Abdullah M. , Alroomi M. , Tse G.
Издательство
Elsevier Ltd
Язык
Английский
Статус
Опубликовано
Номер
104748
Том
82
Год
2022
Организации
  • 1 Dept. of Medical Laboratory Technology, Public Authority for Applied Education and Training, Kuwait
  • 2 Department of Cardiology, Sabah Al Ahmed Cardiac Centre, Al Amiri Hospital, Kuwait City, Kuwait
  • 3 Department of Mathematics and Statistics, University of Strathclyde, Glasgow, G1 1XH, United Kingdom
  • 4 Department of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics Named After V.S. Moiseev, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 5 Department of Endemic and Infectious Diseases, Faculty of Medicine, Suez Canal University, Ismailia, Egypt. Department of Medicine, Division of Gastroenterology, Al Sabah Hospital, Kuwait
  • 6 Department of Medicine, Division of Gastroenterology, Jaber Al Ahmed Hospital, South Surra, Kuwait
  • 7 Department of Medicine, Farwaniya Hospital, Farwaniya, Kuwait
  • 8 Department of Medicine, Al Adan Hospital, Hadiya, Kuwait
  • 9 Department of Emergency Medicine, Mubarak Al-Kabeer Hospital, Jabriya, Kuwait
  • 10 Department of Obstetrics and Gynaecology, Maternity Hospital, Shuwaikh Medical Area, Kuwait
  • 11 Department of Cardiology, Illinois Masonic Medical Center, Chicago, IL, United States
  • 12 Department of Pharmacology & Clinical Pharmacy, College of Medicine & Health Sciences, Sultan Qaboos University, Muscat, Oman & Gulf Health Research, Muscat, Oman
  • 13 Department of Agrometeorology, College of Agriculture, G.B.Pant University of Agriculture & Technology, Pantnagar, Uttarakhand, India
  • 14 Department of Infectious Diseases, Infectious Diseases Hospital, Shuwaikh Medical Area, Kuwait
  • 15 Cardiovascular Analytics Group, Hong Kong, China
  • 16 Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease, Department of Cardiology, Tianjin Institute of Cardiology, Second Hospital of Tianjin Medical University, Tianjin, 300211, China
Ключевые слова
COVID-19; In-hospital mortality; NLR; SARS-CoV-2
Цитировать
Поделиться

Другие записи

Liang J., Gamarra J.G.P., Picard N., Zhou M., Pijanowski B., Jacobs D.F., Reich P.B., Crowther T.W., Nabuurs G.-J., De-Miguel S., Fang J., Woodall C.W., Svenning J.-C., Jucker T., Bastin J.-F., Wiser S.K., Slik F., Hérault B., Alberti G., Keppel G., Hengeveld G.M., Ibisch P.L., Silva C.A., Ter Steege H., Peri P.L., Coomes D.A., Searle E.B., Von Gadow K., Jaroszewicz B., Abbasi A.O., Abegg M., Yao Y.C.A., Aguirre-Gutiérrez J., Zambrano A.M.A., Altman J., Alvarez-Dávila E., Álvarez-González J.G., Alves L.F., Amani B.H.K., Amani C.A., Ammer C., Ilondea B.A., Antón-Fernández C., Avitabile V., Aymard G.A., Azihou A.F., Baard J.A., Baker T.R., Balazy R., Bastian M.L., Batumike R., Bauters M., Beeckman H., Benu N.M.H., Bitariho R., Boeckx P., Bogaert J., Bongers F., Bouriaud O., Brancalion P.H.S., Brandl S., Brearley F.Q., Briseno-Reyes J., Broadbent E.N., Bruelheide H., Bulte E., Catlin A.C., Cazzolla Gatti R., César R.G., Chen H.Y.H., Chisholm C., Cienciala E., Colletta G.D., Corral-Rivas J.J., Cuchietti A., Cuni-Sanchez A., Dar J.A., Dayanandan S., De Haulleville T., Decuyper M., Delabye S., Derroire G., DeVries B., Diisi J., Do T.V., Dolezal J., Dourdain A., Durrheim G.P., Obiang N.L.E., Ewango C.E.N., Eyre T.J., Fayle T.M., Feunang L.F.N., Finér L., Fischer M., Fridman J., Frizzera L., De Gasper A.L., Gianelle D., Glick H.B., Gonzalez-Elizondo M.S., Gorenstein L., Habonayo R., Hardy O.J., Harris D.J., Hector A., Hemp A., Herold M., Hillers A., Hubau W., Ibanez T., Imai N., Imani G., Jagodzinski A.M., Janecek S., Johannsen V.K., Joly C.A., Jumbam B., Kabelong B.L.P.R., Kahsay G.A., Karminov V., Kartawinata K., Kassi J.N., Kearsley E., Kennard D.K., Kepfer-Rojas S., Khan M.L., Kigomo J.N., Kim H.S., Klauberg C., Klomberg Y., Korjus H., Kothandaraman S., Kraxner F., Kumar A., Kuswandi R., Lang M., Lawes M.J., Leite R.V., Lentner G., Lewis S.L., Libalah M.B., Lisingo J., López-Serrano P.M., Lu H., Lukina N.V., Lykke A.M., Maicher V., Maitner B.S., Marcon E., Marshall A.R., Martin E.H., Martynenko O., Mbayu F.M., Mbuvi M.T.E., Meave J.A., Merow C., Miscicki S., Moreno V.S., Morera A., Mukul S.A., Müller J.C., Murdjoko A., Nava-Miranda M.G., Ndive L.E., Neldner V.J., Nevenic R.V., Nforbelie L.N., Ngoh M.L., N’Guessan A.E., Ngugi M.R., Ngute A.S.K., Njila E.N.N., Nyako M.C., Ochuodho T.O., Oleksyn J., Paquette A., Parfenova E.I., Park M., Parren M., Parthasarathy N., Pfautsch S., Phillips O.L., Piedade M.T.F., Piotto D., Pollastrini M., Poorter L., Poulsen J.R., Poulsen A.D., Pretzsch H., Rodeghiero M., Rolim S.G., Rovero F., Rutishauser E., Sagheb-Talebi K., Saikia P., Sainge M.N., Salas-Eljatib C., Salis A., Schall P., Schepaschenko D., Scherer-Lorenzen M., Schmid B., Schöngart J., Šebeň V., Sellan G., Selvi F., Serra-Diaz J.M., Sheil D., Shvidenko A.Z., Sist P., Souza A.F., Stereńczak K.J., Sullivan M.J.P., Sundarapandian S., Svoboda M., Swaine M.D., Targhetta N., Tchebakova N., Trethowan L.A., Tropek R., Mukendi J.T., Umunay P.M., Usoltsev V.A., Vaglio Laurin G., Valentini R., Valladares F., Van der Plas F., Vega-Nieva D.J., Verbeeck H., Viana H., Vibrans A.C., Vieira S.A., Vleminckx J., Waite C.E., Wang H.-F., Wasingya E.K., Wekesa C., Westerlund B., Wittmann F., Wortel V., Zawiła-Niedźwiecki T., Zhang C., Zhao X., Zhu J., Zhu X., Zhu Z.-X., Zo-Bi I.C., Hui C.
NATURE ECOLOGY & EVOLUTION. NATURE PORTFOLIO. Том 6. 2022. С. 1423-1437