MORPHOFUNCTIONAL PECULIARITIES OF THE MYOCARDIUM AND CORONARY MICROVASCULATURE IN EXPERIMENTAL PULMONARY-ARTERY BRANCHES EMBOLISM

Functional parameters of the heart ventricles, subendocardial morphology of anterior and posterior walls (AW and PW) of the right and left ventricles (RV and LV) and the state of coronary microvasculature were studied in experimental research on chinchilla mature rabbits at early (1, 2, 3 days) and late (after 7 and 30 days) stages after pulmonary artery branches embolism (PABE) which had been established by means of vaseline oil injection (0.3 ml/kg) in marginal ear vein. It was found that the heart muscle responded as a whole to the RV overload in PABE, with the structural and functional changes of both ventricles. LV damage develops in parallel with the restoration of the RV reserve possibilities and is more significant and prolonged in the LV PW. Positive correlation exists between the blood supply level of both ventricles PW and the interventricular pressure changes.