The functional role of circular RNAs in the pathogenesis of retinoblastoma: a new potential biomarker and therapeutic target?

Abstract Retinoblastoma (RB) is a common cancer in infants and children. It is a curable disease; however, a delayed diagnosis or treatment makes the treatment difficult. Genetic mutations have a central role in the pathogenesis of RB. Genetic materials such as RNAs (coding and non-coding RNAs) are also involved in the progression of the tumor. Circular RNA (circRNA) is the most recently identified RNA and is involved in regulating gene expression mainly through “microRNA sponges”. The dysregulation of circRNAs has been observed in several diseases and tumors. Also, various studies have shown that circRNAs expression is changed in RB tissues. Due to their role in the pathogenesis of the disease, circRNAs might be helpful as a diagnostic or prognostic biomarker in patients with RB. In addition, circRNAs could be a suitable therapeutic target to treat RB in a targeted therapy approach.

Authors
Kouhi Esfahani Niloofar 1 , Karami Fath Mohsen , Pourbagher Benam Sasan , Shahkarami Negar , Shafa Shahriyar , Bagheri Hossein , Shafagh Seyyed-Ghavam , Payandeh Zahra , Barati Ghasem
Status
Published
Year
2023
Organizations
  • 1 Peoples Friendship University of Russia
Keywords
Retinoblastoma; Non-coding RNA; Circular RNA; Biomarker; Cancer therapy
Date of creation
21.04.2023
Date of change
21.04.2023
Short link
https://repository.rudn.ru/en/records/article/record/93414/
Share

Other records