The paper deals with national cultures influence on economic performance. Main aim is to analyze the impact of national culture on entrepreneurial activity in various countries. The study explores Geert Hof-stede’s cultural dimensions that allow assessing influence of main values and special features of mentality on behavioral patterns. The authors analyze an interaction between masculinity and individualism and a level of entrepreneurial activity in various countries by means of a multivariate correlation analysis. The authors use Total Early - stage Entrepreneurial Activity for entrepreneurial activity assessment. To assess business environment the authors use Ease of Doing Business indexes, developed by the World Bank: DTF score for starting a business, DTF score for getting credit and DTF score for paying taxes and also adjusted net national income per capita. The authors conclude that masculinity and individualism determine key factors influencing TEA.