As a result of 10-year follow-up study of 250 patients with diabetes mellitus, type 1 (58) and type 11 (192) 4 predictable psychological crises have been singled out: the first one was related to reaction to the diagnosis; the second - to the assignment of insulin therapy; the third - to the development of diabetes complications and the fourth - to hospitalization and a subsequent communication with other, more "experienced", patients. In the progress of the disease, an interaction of psychogenic, somatic and personality factors caused development of psycho-somatic cycles (psycho-somatic balancing according to H. Baruk), which is realized in 3 variants: predominantly psychogenic, predominantly somatic and psycho-somatic.