Specific disturbances of psychomotor development in children with thymomegaly

Ninety children, aged from 2 month to 3 years, with thymomegaly and 25 aged-matched controls were studied. Most children with thymomegaly had disturbances of psychomotor development. Depending on their types, the cohort of children was stratified into 4 subgroups: 1(st) - 36 patients (40%) with schizotypal signs; 2(nd) - 30 hyperactive children (33%); 3(rd) - 19 children with hyperthymia signs (21%); 4(th) - 5 normal children (6%). The deviations of locomotion and psychiatric development were correlated with the extent of thymus enlargement and activation of innate and adaptive immunity.