Optimization of interferon-and immunotherapy in immunocompromised children with associated viral infections

The treatment of immunocompromised children with high-frequency of recurrent associated viral infections is very difficult. We had studied 2 groups of children with recurrent acute respiratory viral infections, combined with mono- and mixed-herpes viral infection, revealed significant defects in phagocytic and microbicidal activity NG, deficit serum IFN alpha and IFN gamma. We had created the program of therapy which included for one group of patients recombinant IFN alpha, izoprinozin and for another group of patients - recombinant IFN alpha, izoprinozin and additional - licopid. Adequate doses of recombinant IFN alpha promoted significant increase in levels of IFN alpha and IFN gamma, application of licopid restored disturbed functions of NG. The developed program optimized interferon-and immunotherapy had a high clinical efficiency.