Genomics of elastic fiber synthesis. Practical meaning for cosmetologists and dermatologists

The skin mechanical properties are realized mainly due to the extracellular matrix of the dermis consisting mostly of collagen and elastic fibers and hyaluronan (hyaluronic acid). Each of these components is responsible for different mechanical properties. In particular, elastic fibers are responsible for the skin elasticity (its ability to return to its original shape when stretched after tensile force end). If the function of elastic fibers is impaired the skin looks overstretched, loose and flabby. It is known that the synthesis of extracellular matrix components is carried out by fibroblasts however the turnover of collagen and elastic fibers as well as hyaluronic acid has its own characteristics and factors that affect the turnover completeness. Objective. To analyze and systematize studies on elastic fibers’ synthesis in the skin as well as potential genes responsible for their turnover. This will help to better understand the complex multi-step process of assembly and degradation of elastic fibers as well as prepare a personalized approach to the management of patients by cosmetologists and dermatologists. © N.N. POTEKAEV, O.B. BORZYKH, N.A. SHNAYDER, M.M. PETROVA, E.I. KARPOVA, O.M. DEMINA, O.V. ZHUKOVA, R.F. NASYROVA.