Objective. To analyze the parameters characterizing various aspects of quality of life, adherence to treatment and satisfaction with it in patients receiving a regimen of ART consisting of domestic medications. Patients and methods. A questionnaire survey of 49 patients with HIV infection was conducted. All respondents received ART for 48 weeks, which included domestic medications: 2 nucleoside reverse transcriptase inhibitors (phosphazide + lamivudine in one tablet) and a non-nucleoside reverse transcriptase inhibitor (elsulfavirine). Conclusion. The data obtained at week 48 of ART with domestic medications phosphazide/lamivudine (Phosphaladine) and elsulfavirine showed that most patients were satisfied with the treatment they received, its convenience and severity of side effects. The adherence rate to this regimen was high. © 2022, Dynasty Publishing House. All rights reserved.