Aim. Article is to detail the positive and negative aspects associated with the creation of a glide path with various types of endodontic instruments. Materials and methods. During a systematic review of the literature, Russian - and English-language publications were studied in the electronic databases PubMed, Google Scholar. Articles, the content of which concerns the methods of creating a glide path, as well as possible complications were included in analysis. Results. 60 articles were reviewed during the review. After analyzing the literature according to the inclusion and exclusion criteria, the total number of publications has become 32. Conclusions. according to the studied literature, it can be said that the glide path provides a predictable behavior of rotary tools and it is a recommended condition for achieving the success of endodontic treatment at the stage of canal mechanical treatment and preventing iatrogenic complications.