Clinical and Immunological Features of Hemorrhagic Fever with Renal Syndrome

Hemorrhagic fever with renal syndrome (HFRS) is a feral herd disease caused by hantaviruses which manifestations include hemorrhages and renal disorder. HFRS may be severe. Disease severity is generally tailored to immune mechanisms. The role of innate lymphocytes, i.e., NK cells and NKT, still remains elusive. Our study demonstrated that T helper cell blood count decreases in HFRS while the number of NKT and regulatory T cells increases. Severe HFRS develops under functional predomination of regulatory T cells, cytotoxic T cells plays the key role while B cells and innate immune cells are less important.