Single nucleo tide polymorphisms in cytokine genes and their role in the pathogenesis of cardiac , vascular and pulmonary diseases

The purpose of the literature review is to analyze the current data on the influence of cytokine gene polymorphisms on the occurrence, course, manifestations and outcomes of the most common cardiac, vascular and pulmonary diseases, in the pathogenesis of which inflammation plays a significant role. The range of cytokines under consideration includes classes that potentiate the inflammatory process (pro-inflammatory cytokines), which include TNF-α, IL-1, IL-6, IL-12, IL-13, IL-17 and IL-33, and its inhibitors (anti-inflammatory), such as IL-10, IL-4, TGF-β. The role of cytokine polymorphismsin the development of dilated cardiomyopathy, ischemic heart disease, heart failure, stroke, bronchial asthma and chronic obstructive pulmonary disease is discussed. The data obtained so far indicate that the content and severity of the effect of cytokine gene polymorphisms on the pathological process depends on the polymorphic locus location, its effect on gene expression, the combination of polymorphism alleles and the ethnic characteristics of patients. © 2021 Stavropol State Medical University. All rights reserved.

Authors
Pirozhkov S.V.1 , Peregud D.I.2 , Terebilina N.N. 2 , Litvitskiy P.F.1 , Kabaeva E.N. 3
Publisher
Stavropol State Medical University
Number of issue
1
Language
Russian
Pages
103-109
Status
Published
Volume
16
Year
2021
Organizations
  • 1 I. M. Sechenov First Moscow State Medical University (Sechenov University), Russian Federation
  • 2 V. P. Serbsky National Medical Research Center for Psychiatry and Addiction, Moscow, Russian Federation
  • 3 Peoples' Frendship University, Moscow, Russian Federation
Keywords
bronchial asthma; chronic obstructive pulmonary disease; cytokines; dilated cardiomyopathy; single nucleotide polymorphism; stroke
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/77234/
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