Cancer surgery on face due to basal cell carcinoma forms large defects and deformities. Sometimes the defects are being surgically reconstructed. The quality of life of patient after surgery for facial skin cancer needs immediate reconstruction to solve not only somatic, but also psychological esthetically affected problems. Plastic, surgical reconstruction sometimes is a good method of choice if the defect covers upper face components or soft tissue segments of buccal region. In exenteration of orbit or total nasal surgery due to cancer it can be problematic because of impossibility of adequate esthetic restoration failure. There are many cases, when plastic surgery is not enough for facial defect reconstruction. In majority of cases mid-face defect includes a whole organ as eye and/or orbit, or nose and the quantity of remaining soft and bone tissue limits soft and hard tissue grafting. The only method of mid-face reconstruction after orbit exenteration is orbital epithesis fabrication and defect prosthetic treatment. With good esthetic results, this method makes possible further cancer surgery results monitoring, which is so important for the patient before survival rate of 5 years. 3D planning and mid-face printing solve the problem of orbital defect prosthetic reconstruction in early stages of post-cancer treatment with non-delayed methodology of 3D planning and printing. For better esthetic appearance iris of ocular is color matched in digital technologies and printed on an ink printer, technologically covered with several acrylic layers for further color stability. The epitasis itself is made of platinum silicones. Volcanization mode is preferred with heat curing in a dry oven. Mechanical properties of silicone epithesis are enhanced mixing thixotropic agents into silicone mixture before packing silicone in flask to have a good consistence after de-flasking the epithesis. © 2021, Yerevan State Medical University. All rights reserved.