The use of piezosurgery in dentistry is increasingly widespread, but a comparative analysis of this relatively new method with traditional osteotomy techniques is necessary. The work aims to compare effectiveness of standard dental treatment methods with piezosurgery. The study was conducted in 2018-19 at the Institute of Dentistry at Sechenov University and Peoples Frendship University of Russia. A total of 178 patients diagnosed with acquired edentulism were subdivided into two groups: Group 1 with standard osteotomy methods used, Group 2 with piezosurgical methods used. Only 4% of Group 2 patients and 60% of Group 1 patients (p≤0.0001) experienced bleeding. Group 2 patients were discharged within the first two days of surgery and group 1 patients were discharged within four days (p≤0.05). The use of piezoesurgical techniques reduces probability of complications by a factor of 4 in Group 2 versus Group 1. Postoperative rehabilitative period in Group 2 was 20% shorter. Analysis of reoparodontogram indicated that vasoconstriction of regional vessels was observed in Group 2 and was eliminated one month after the operation. © 2021, Journal of International Dental and Medical Research. All Rights Reserved.