Matrices for Tissue Engineering Based on Ultrafine Fibers and Microparticles of Poly(hydroxybutyrate)

Abstract: The structure and diffusion properties of combined ultrafibrous matrices containing microspheres for prolonged release of lysozyme are studied in the work. The matrices are biocompatible and they are not cytotoxic. The matrices are obtained via electrospinning. These materials are suitable for solving problems of tissue engineering, since they combine ultrafine fibers of poly(hydroxybutyrate) promoting effective attachment and growth of cells and poly(hydroxybutyrate) microparticles capable of prolonged release of a bioactive compound. These properties allow one to recommend these matrices for tissue engineering. © 2021, Pleiades Publishing, Ltd.

Authors
Bonartsev A.P. 1 , Ol’khov A.A.2, 3 , Khan O.I. 4 , Kucherenko E.L.5 , Filatova A.G.5 , Zernova Y.N.5 , Iordanskii A.L.5
Journal
Inorganic Materials: Applied Research
Publisher
Maik Nauka Publishing / Springer SBM
Number of issue
4
Language
English
Pages
974-979
Status
Published
Link
External link
DOI
10.1134/S2075113321040080
Volume
12
Year
2021
Organizations
  • 1 Moscow State University, Moscow, 119991, Russian Federation
  • 2 Plekhanov Russian University of Economics, Moscow, 117997, Russian Federation
  • 3 Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Moscow, 119334, Russian Federation
  • 4 Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 5 Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Keywords
biocompatible matrices; electrospinning; lysozyme; microspheres; poly(hydroxybutyrate); prolonged release; ultrafine fibers
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