Studying the physiological effects of a new model of septoplasty in rats

Physiological responses to the proposed rat septoplasty model under general anesthesia were investigated. We studied the motor activity of rats and heart rate variability before experiment, one day and two days after surgery. After surgical intervention, motor activity decreased, the time of fading and grooming increased, the value of HF decreased, and VLF increased. Surgical trauma of the nasal septum mucous membrane in rats in the early postoperative stage contributes to a powerful stress response in the form of a shift in the balance of the autonomic nervous system towards the sympathetic nervous system, causes mobilization of central regulation mechanisms, reduces research activity, and provokes an anxious, depressive-like state and anxiety in rats. © 2020 All-Russian Federation of the Specialists in Head and Neck Diseases. All rights reserved.

Authors
Kastyro I.V. 1 , Reshetov I.V.2 , Popadyuk V.I. 1 , Torshin V.I. 1 , Ermakova N.V. 1 , Karpukhina O.V.3 , Inozemtsev A.N. 3 , Khamidulin G.V. 1 , Shmaevsky P.E. 1 , Sardarov G.G. 1 , Gordeev D.V. 1 , Scopich A.A. 1
Journal
Голова и шея. Российское издание. Журнал Общероссийской общественной организации "Федерация специалистов по лечению заболеваний головы и шеи"
Number of issue
2
Language
Russian
Pages
33-38
Status
Published
Link
External link
DOI
10.25792/HN.2020.8.2.33-38
Volume
8
Year
2020
Organizations
  • 1 FSAEI HE Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 2 FSAEI HE I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
  • 3 FSBEI HE Lomonosov Moscow State University, Moscow, Russian Federation
Keywords
Centralization index; Grooming; Heart rate variability; HF; LF; Motor activity; Septoplasty; Stress; VLF
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