Three-component reactions of 3-arylidene-3h-indolium salts, isocyanides and amines

A multicomponent reaction of isocyanides with aryl(indol-3-yl)methylium salts and amines has been found. A series of aryl(indol-3-yl)acetimidamides was obtained in up to 96% yields. In the case of ethyl isocyanoacetate, the reaction is followed by cyclization to form 3,5-dihydro-4H-imidazol-4-one derivatives. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Authors
Nguyen H.M. 1, 2 , Golantsov N.E. 1 , Golubenkova A.S. 1 , Rybakov V.B. 3 , Voskressensky L.G. 1
Journal
Molecules
Publisher
MDPI AG
Number of issue
9
Language
English
Status
Published
Link
External link
DOI
10.3390/MOLECULES26092402
Number
2402
Volume
26
Year
2021
Organizations
  • 1 Department of Organic Chemistry, Faculty of Science, Peoples’ Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 2 Faculty of Natural Sciences, Hung Vuong University, Nguyen Tat Thanh Street, Viet Tri, 35120, Viet Nam
  • 3 Faculty of Chemistry, Lomonosov Moscow State University, 1-3 Leninskiye Gory, Moscow, 119991, Russian Federation
Keywords
Carbenium ions; Imidamides; Imidazolones; Indoles; Isocyanides; Multicomponent reactions
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