URIC ACID AS A RISK FACTOR FOR CATARACTS IN PATIENTS WITH GOUT

AIM. To determine the concentration of uric acid in body fluids and its relationship with the development of cataract. METHODS. The study included 170 patients with male cataracts, aged 30 to 75 years, who were divided into two groups: the first group (control) - patients without gout 60 patients (60 eyes), the second group (study) - patients with cataract complicated by gout 110 patients (110 eyes). All patients signed an informed consent to participate in the study and the processing of personal data. In addition to standard ophthalmic research methods, all patients were also determined: the level of uric acid in the blood serum, in the tear and in the moisture of the anterior chamber. The diagnosis of gout is established by signs of ACR/EULAR (2015). Microsoft Excel 2019 and Statistic 20. These parameters allow you to analyze deviations from the normal, a comparison of two independent groups using the non-parametric Mann-Whitney test. Data were median (25%; 75% percentile). Differences at which p <0.05 are considered statistically significant. RESULTS. The concentration of uric acid in biological fluids in patients of the study group was significantly increased compared with patients in the control group (p <0.0001) CONCLUSIONS. In patients with cataracts and with concomitant gout disease, an increase in the concentration of uric acid is observed not only in the blood, but also in the tear and moisture of the anterior chamber, which may be a risk factor for the development of cataracts. Measuring the concentration of uric acid in body fluids can be a useful tool for monitoring the health status and condition of eye tissues.